Activation of mTORC1 is essential for beta-adrenergic stimulation of adipose browning
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چکیده
Activation of mTORC1 is essential for beta-adrenergic stimulation of adipose browning" (2016).
منابع مشابه
Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.
A classic metabolic concept posits that insulin promotes energy storage and adipose expansion, while catecholamines stimulate release of adipose energy stores by hydrolysis of triglycerides through β-adrenergic receptor (βARs) and protein kinase A (PKA) signaling. Here, we have shown that a key hub in the insulin signaling pathway, activation of p70 ribosomal S6 kinase (S6K1) through mTORC1, is...
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OBJECTIVE Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white fat (termed 'browning'), has great therapeutic potential to treat obesity and its comorbidities because of the net increase in energy expenditure. β-adrenergic-cAMP-PKA signaling has long been known to regulate these processes. ...
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تاریخ انتشار 2017